Calcineurin Mediates Bladder Smooth Muscle Hypertrophy After Bladder Outlet Obstruction
نویسندگان
چکیده
منابع مشابه
Calcineurin mediates bladder wall remodeling secondary to partial outlet obstruction.
We hypothesized that the calcineurin-nuclear factor of activated T-cells (NFAT) pathway is activated following partial bladder outlet obstruction (pBOO), which would allow for pharmacologic treatment to prevent the ensuing bladder wall hypertrophy. Using a model of pBOO in male mice, we were able to demonstrate increased nuclear importation of the transcription factors NFAT and myocyte enhanchi...
متن کاملPartial bladder outlet obstruction induces urethral smooth muscle hypertrophy and decreased force generation.
PURPOSE PBOO leads to increased urinary frequency, decreased void volume, hypertrophy of the detrusor SM, and alterations in contractile and regulatory proteins. This study was done to determine whether PBOO induced increases in urinary frequency and detrusor SM hypertrophy are associated with an alteration in the contractility and expression of myosin isoforms in urethral SM. MATERIALS AND M...
متن کاملThe detrusor muscle: an innocent victim of bladder outlet obstruction.
OBJECTIVES Benign prostatic hyperplasia (BPH) is considered a frequent cause of bladder outlet obstruction (BOO) and lower urinary tract symptoms (LUTS), although the physiopathologic mechanism through which BPH causes LUTS is not clear. Several morphologic and functional modifications of the bladder detrusor have been described in patients with BPH and could play a direct role in determining s...
متن کاملPartial bladder outlet obstruction abolishes the receptor- and G protein-dependent increase in calcium sensitivity in rabbit bladder smooth muscle.
Partial bladder outlet obstruction (PBOO) alters the function of the whole bladder and produces specific alterations in the contractility of the bladder smooth muscle cell. The goal of this study was to test the hypothesis that PBOO affects smooth muscle contraction at the level of the receptor- and G protein-dependent increase in myofilament Ca2+ sensitivity. To address this question, we used ...
متن کاملPartial bladder outlet obstruction alters Ca sensitivity of force, but not of MLC phosphorylation, in bladder smooth muscle
Michaela C. Stanton,1 Michele Clement,2 Edward J. Macarak,3 Stephen A. Zderic,2 and Robert S. Moreland1 1Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia 19102; 2Department of Urology, The Children’s Hospital of Philadelphia, Philadelphia 19101; and 3Department of Anatomy and Cell Biology, University of Pennsylvania School of Dental Medicine, Philad...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Urology
سال: 2003
ISSN: 0022-5347,1527-3792
DOI: 10.1097/01.ju.0000081460.23737.63